Effect of inflammatory arthritis on dexamethasone receptors in phagocytes—a possible role for plasma factors
Identifieur interne : 003791 ( Main/Exploration ); précédent : 003790; suivant : 003792Effect of inflammatory arthritis on dexamethasone receptors in phagocytes—a possible role for plasma factors
Auteurs : Isobel P. Braidman [Royaume-Uni] ; K. Livingston [Royaume-Uni] ; I. W. Tomlinson [Royaume-Uni] ; M. I. V. Jayson [Royaume-Uni] ; M. K. Jasani [Royaume-Uni]Source :
- Agents and Actions [ 0065-4299 ] ; 1981-06-01.
English descriptors
- Teeft :
- Adherence assay, Allogeneic effect, Antibody responses, Arthritis, Available binding sites, Basel effect, Binding affinity, Blood pmnls, Cell adherence, Cellular cooperation, Dexamethasone, Dexamethasone binding, Glass tubes, Immune type, Inflammatory, Inflammatory disease, Intrinsic effect, Leukocyte, Leukocyte adherence inhibition test, Levamisole, Lymphocyte, Mononuclear, Mononuclear cells, Nonimmune inflammation, Pmnls, Polyarthritic, Polyarthritic patients, Polymorphonuclear cells, Receptor, Rheumatoid, Rheumatoid arthritis, Rheumatoid plasma, Seropositive, Synovial, Synovial fluid, Synovial fluid cells, Synovial tissue cells, Total leukocytes.
Abstract
Abstract: Synovial tissue cells from patients with seropositive rheumatoid arthritis bind dexamethasone in a similar fashion to the classical steroid receptors on other cells. In contrast, synovial fluid cells and blood PMNLs from these patients bind dexamethasone with much reduced affinity. Some component of plasma may interfere with the binding of dexamethasone to its receptor.
Url:
DOI: 10.1007/BF01978758
Affiliations:
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Jasani</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Ciba Geigy Research Centre, Horsham, Sussex</wicri:regionArea><wicri:noRegion>Sussex</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Agents and Actions</title><title level="j" type="abbrev">Agents and Actions</title><idno type="ISSN">0065-4299</idno><idno type="eISSN">1420-908X</idno><imprint><publisher>Birkhäuser-Verlag</publisher><pubPlace>Basel</pubPlace><date type="published" when="1981-06-01">1981-06-01</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">6-7</biblScope><biblScope unit="page" from="602">602</biblScope><biblScope unit="page" to="604">604</biblScope></imprint><idno type="ISSN">0065-4299</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0065-4299</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adherence assay</term><term>Allogeneic effect</term><term>Antibody responses</term><term>Arthritis</term><term>Available binding sites</term><term>Basel effect</term><term>Binding affinity</term><term>Blood pmnls</term><term>Cell adherence</term><term>Cellular cooperation</term><term>Dexamethasone</term><term>Dexamethasone binding</term><term>Glass tubes</term><term>Immune type</term><term>Inflammatory</term><term>Inflammatory disease</term><term>Intrinsic effect</term><term>Leukocyte</term><term>Leukocyte adherence inhibition test</term><term>Levamisole</term><term>Lymphocyte</term><term>Mononuclear</term><term>Mononuclear cells</term><term>Nonimmune inflammation</term><term>Pmnls</term><term>Polyarthritic</term><term>Polyarthritic patients</term><term>Polymorphonuclear cells</term><term>Receptor</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Rheumatoid plasma</term><term>Seropositive</term><term>Synovial</term><term>Synovial fluid</term><term>Synovial fluid cells</term><term>Synovial tissue cells</term><term>Total leukocytes</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Synovial tissue cells from patients with seropositive rheumatoid arthritis bind dexamethasone in a similar fashion to the classical steroid receptors on other cells. In contrast, synovial fluid cells and blood PMNLs from these patients bind dexamethasone with much reduced affinity. Some component of plasma may interfere with the binding of dexamethasone to its receptor.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Braidman, Isobel P" sort="Braidman, Isobel P" uniqKey="Braidman I" first="Isobel P." last="Braidman">Isobel P. Braidman</name></noRegion><name sortKey="Jasani, M K" sort="Jasani, M K" uniqKey="Jasani M" first="M. K." last="Jasani">M. K. Jasani</name><name sortKey="Jayson, M I V" sort="Jayson, M I V" uniqKey="Jayson M" first="M. I. V." last="Jayson">M. I. V. Jayson</name><name sortKey="Livingston, K" sort="Livingston, K" uniqKey="Livingston K" first="K." last="Livingston">K. Livingston</name><name sortKey="Tomlinson, I W" sort="Tomlinson, I W" uniqKey="Tomlinson I" first="I. W." last="Tomlinson">I. W. 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